Symptoms of histamine intolerance: signs, causes, and detection

Birgit was in her mid-forties when she noticed that something was wrong with her body. Sometimes she suffered from diarrhea, at other times from constipation. Dizziness, headaches, and concentration problems were also frequent occurrences. Her skin was also becoming increasingly sensitive: hives, itching, skin redness, and sudden facial flushing had become part of her daily life. On top of that, she experienced heart palpitations, stomach cramps, abdominal pain, and bloating.

Like many sufferers, Birgit visited numerous doctors. However, the examinations showed no clear abnormalities. Blood values, hormone levels, and other laboratory findings were within the normal range. Although her symptoms were a heavy burden, she did not receive a clear diagnosis.

It was only after intensive personal research and the support of a specialist for food intolerances that she found the cause of her symptoms: histamine intolerance.

Histamine intolerance: Often unrecognized despite diverse symptoms

Does this story sound familiar to you? You are not alone. Many people with histamine intolerance suffer from non-specific symptoms for years before the actual cause is identified.

The symptoms of histamine intolerance can vary greatly. The most common complaints include:

Headaches and migraines
Dizziness
Skin redness, itching, and hives
Heart palpitations
Stomach cramps and abdominal pain
Bloating
Diarrhea or other digestive issues
Fatigue and general malaise

Why are the symptoms of histamine intolerance so varied?

Histamine is a body-own messenger substance involved in numerous processes. Many organs and tissues possess so-called histamine receptors, where histamine can take effect. This is why histamine intolerance can manifest in different parts of the body.

While some sufferers primarily experience digestive problems, others deal mainly with skin reactions, cardiovascular issues, or neurological symptoms such as headaches and dizziness. The intensity and combination of symptoms can vary significantly from person to person.

Recognizing histamine intolerance and getting a proper diagnosis

If you suffer regularly from the aforementioned symptoms and no clear cause has been found, histamine intolerance could be a possible explanation. Medical clarification and individual consultation are important to rule out other diseases and to find appropriate measures.

An early diagnosis can help to reduce symptoms and improve long-term well-being.

Written by Martin Monzel

DAO explained simply

What is a DAO?

DAO (diamine oxidase) is an enzyme that breaks down histamine in the body – primarily in the gut.

What role does DAO play in histamine intolerance?

If there is too little DAO available or the enzyme is not functioning sufficiently, histamine cannot be broken down as effectively and may potentially accumulate.
Reduced DAO activity is frequently associated with histamine intolerance. Typical symptoms can include headaches, skin reactions, or digestive problems.

Can I support my DAO?

Many affected individuals pay attention to a histamine-conscious diet and a mindful lifestyle. Some additionally use DAO-containing supplements. The quick solution is the intake of the enzyme, but a long-term intestinal rehabilitation is often useful as well. This is because as soon as histamine-producing bacteria occur in increased numbers in the gut, histamine can also accumulate even if enough DAO is present. In that case, however, it can no longer keep up with breaking down the excess.

Is DAO measurable?

DAO activity can be measured in the blood. However, a single value is usually not sufficient to clearly establish histamine intolerance. This makes diagnosing the condition based on values alone often difficult.

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